Florence (Firenze) — the capital of Tuscany, a city of 380,000 people on the Arno River, a UNESCO World Heritage Site — is the intellectual and artistic birthplace of the Renaissance: the movement that ended the medieval world and began the modern one began here, in the 14th and 15th centuries, when the Medici banking family's extraordinary wealth funded a flowering of art, architecture and humanist thought that produced Brunelleschi, Donatello, Botticelli, Leonardo da Vinci, Michelangelo and Galileo within the span of two centuries, transforming a prosperous medieval merchant city into the cultural capital of the Western world. The density of world-class art within Florence's historic centre — concentrated in an area walkable in a long morning — is unmatched anywhere on earth: the Uffizi Gallery alone contains more masterpieces of European painting than any other building in the world.
Brunelleschi's dome (il Duomo di Santa Maria del Fiore) — the engineering marvel that ended the medieval period and announced the Renaissance, completed in 1436, the largest brick dome ever constructed (44.9 metres internal diameter) — dominates the Florence skyline and remains the city's most powerful symbol: a building that solved an engineering problem that had defeated every architect for 100 years (the completion of the cathedral's crossing, with a dome spanning 43 metres without the traditional wooden centering support structure), using an innovative herringbone brick pattern and double-shell construction that Brunelleschi invented and kept secret. The climb to the dome lantern (463 steps, no lift) gives the finest elevated view of Florence and Tuscany beyond.
The Uffizi Gallery
The Uffizi (Galleria degli Uffizi) — commissioned by Cosimo I de' Medici in 1560 as the offices of the Florentine government, converted to a museum in the 18th century — contains the most complete collection of Italian Renaissance painting in existence: Botticelli's Birth of Venus and Primavera (Room 10–14, the most reproduced Italian paintings in the world), Leonardo da Vinci's Adoration of the Magi and Annunciation, Michelangelo's Doni Tondo (the only finished easel painting attributable to Michelangelo), Raphael's Portrait of Leo X, Caravaggio's Medusa, Titian's Venus of Urbino and hundreds of works of comparable calibre. The full Uffizi requires 3–4 hours for a serious visit; a targeted 90-minute visit to the highlights (rooms 2, 3, 7, 10–14, 15, 25, 28, 55, 83, and the Caravaggio rooms) is possible with good planning. Book online at uffizi.it — in-person queues in summer can exceed 2 hours even for pre-booked tickets.
Michelangelo's David & the Accademia
Michelangelo's David — the 5.17-metre marble statue of the Biblical hero David, carved between 1501 and 1504 from a single block of Carrara marble that had been abandoned as unworkable for 25 years, displayed in the purpose-built rotunda of the Galleria dell'Accademia since 1873 — is one of the world's most recognisable and most discussed works of art: a figure of extraordinary physical idealism and psychological tension (the subtle turn of the head, the tense left hand, the relaxed right, capturing the moment of decision before battle) that represents the high-water mark of Renaissance figural sculpture. The Accademia also houses a series of Michelangelo's Prisoners (the unfinished figures emerging from their marble blocks, a remarkably powerful accompaniment to the David's perfection), several important altarpieces and a fine collection of Florentine Gothic painting. Book at uffizi.it (the Accademia is managed by the same organisation) — queues without pre-booking are substantial.
Ponte Vecchio, Oltrarno & Tuscany
The Ponte Vecchio — the medieval bridge over the Arno, its shops (originally butchers, now goldsmiths and jewellers by a Medici decree of 1593 that expelled the butchers for their smell) and the Vasari Corridor (the secret passageway Cosimo I built above the bridge to connect the Uffizi to the Palazzo Pitti without touching public streets) making it the most photographed bridge in Italy — is best seen from the Ponte Santa Trinita (the next bridge upstream) in the early morning or at sunset. The Oltrarno neighbourhood (the south bank of the Arno) is less touristic than the historic centre: the Boboli Gardens (behind the Palazzo Pitti, a 16th-century formal garden with fountains and statuary), the Brancacci Chapel (Masaccio's revolutionary 15th-century frescoes, €8, very limited capacity — book ahead) and the San Miniato al Monte church (on the hill above the Oltrarno, one of the finest Romanesque buildings in Italy, with extraordinary Intarsia choir stalls) are all worth the short walk across the river. Day trips to the Chianti wine region (30–45 minutes by car or bus) or Siena (90 minutes by bus) complete a Tuscany itinerary.